Laboratorio di Biologia Molecolare
Prof. Vito De Pinto
Dipartimento di Scienze Chimiche - Universitā di Catania

















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Characterization of human VDAC isoforms: a peculiarfunction for VDAC3?

De Pinto V., Guarino F., Guarnera A., Messina A., Reina S., Tomasello F.M., Palermo V., Mazzoni C.
Biochim Biophys Acta. 2010 Feb 6. [Epub ahead of print]- PubMed

Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis.
Tomasello F, Messina A, Lartigue L, Schembri L, Medina C, Reina S, Thoraval D, Crouzet M, Ichas F, De Pinto V, De Giorgi F.
Cell Res. 2009 Dec;19(12):1363-76. Epub 2009 Aug 11.Pubmed

Carnosinase levels in aging brain: redox state induction and cellular stress response.
Bellia F, Calabrese V, Guarino F, Cavallaro M, Cornelius C, De Pinto V, Rizzarelli E.
Antioxid Redox Signal. 2009 Nov;11(11):2759-75. Pubmed

Two structurally different rituximab-specific cd20 mimotope peptides reveal that Rituximab recognizes two different cd20-associated epitopes.
F. Perosa, E. Favoino, C. Vicenti, A. Guarnera, V. De Pinto, F. Dammacco
(2009) J. Immunology 182, 416-422 - PubMed

Molecular and functional characterization of VDAC2 purified from mammal spermatozoa  
V. A. Menzel, M. C. Cassarā, R. Benz, V. De Pinto, A. Messina, V. Cunsolo, R. Saletti, K. D. Hinsch, E. Hinsch
(2008) Bioscience Reports  -
PubMed
 
Porin isoform 2 has a different localization in Drosophila melanogaster ovaries
than porin 1

V. Specchia, F. Guarino, A. Messina, M.P. Bozzetti, V. De Pinto
(2008)
J. Bioenerg. Biomembr., 40, 219-226 - PubMed

The structure of Voltage-Dependent Anion selective Channel: state of the art
V. De Pinto, S. Reina, F. Guarino, A. Messina
(2008) Invited review in J. Bioenerg. Biomembr., 40, 139-147 - PubMed

Genetic structure of the killifish Aphanius fasciatus, Nardo 1827 (Teleostei, Cyprinodontidae), results of mitochondrial DNA analysis.
A.M. Pappalardo, V. Ferrito, A. Messina, F. Guarino, T. Patarnello V. De Pinto and C. Tigano
(2008) J. of Fish Biology, 72, 1154-1173


Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore.
De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrė A, Milardi D, Pappalardo G.
(
2007) Chembiochem. May 7;8(7):744-56.  PubMed

Expression and localization in spermatozoa of the mitochondrial porin isoform 2 in Drosophila melanogaster.
Guarino F, Specchia V, Zapparoli G, Messina A, Aiello R, Bozzetti MP, De Pinto V.
(2006) Biochem Biophys Res Commun. 346(3):665-70. Epub 2006 Jun 6.
PubMed


Voltage-dependent anion-selective channel 1 (VDAC1)--a mitochondrial protein, rediscovered as a novel enzyme in the plasma membrane.
Lawen A, Ly JD, Lane DJ, Zarschler K, Messina A, De Pinto V.
(2005) Int J Biochem Cell Biol. 37(2):277-82.
PubMed


Functional characterization of a second porin isoform in Drosophila melanogaster. DmPorin2 forms voltage-independent cation-selective pores.
Aiello R, Messina A, Schiffler B, Benz R, Tasco G, Casadio R, De Pinto V.
(2004) J Biol Chem. 279(24):25364-73. - PubMed

Voltage-dependent anion-selective channels VDAC2 and VDAC3 are abundant proteins in bovine outer dense fibers, a cytoskeletal component of the sperm flagellum.
Hinsch KD, De Pinto V, Aires VA, Schneider X, Messina A, Hinsch E.
J Biol Chem. 2004 Apr 9;279(15):15281-8. Epub 2004 Jan 22.
PubMed

VDAC1 is a transplasma membrane NADH-ferricyanide reductase.
Baker MA, Lane DJ, Ly JD, De Pinto V, Lawen A.
(2004) J Biol Chem. 279(6):4811-9. PubMed

New functions of an old protein: the eukaryotic porin or voltage dependent anion selective channel (VDAC).
De Pinto V, Messina A, Accardi R, Aiello R, Guarino F, Tomasello MF, Tommasino M, Tasco G, Casadio R, Benz R, De Giorgi F, Ichas F, Baker M, Lawen A.
(2003) Ital J Biochem. 52(1):17-24.
PubMed


A genetic analysis of the porin gene encoding a voltage-dependent anion channel protein in Drosophila melanogaster.
Oliva M, De Pinto V, Barsanti P, Caggese C.
(2002) Mol Genet Genomics. 267(6):746-56.  - PubMed

A 3D model of the voltage-dependent anion channel (VDAC).
Casadio R, Jacoboni I, Messina A, De Pinto V.
(2002) FEBS Lett. 520(1-3):1-7.
PubMed

Prediction of the transmembrane regions of beta-barrel membrane proteins with a neural network-based predictor
I. Jacoboni, P. L. Martelli, P. Fariselli, V. De Pinto and R. Casadio
(2001) Protein Science, 10, 779-87
PubMed

Characterization of channel-forming activity in muscle biopsy from a porin-deficient human patient.

De Pinto V, Messina A, Schmid A, Simonetti S, Carnevale F, Benz R
(2000) J Bioenerg Biomembr. 32(6):585-93.
PubMed

Extramitochondrial porin: facts and hypotheses.
Báthori G, Parolini I, Szabó I, Tombola F, Messina A, Oliva M, Sargiacomo M, De Pinto V, Zoratti M.
(2000) J Bioenerg Biomembr. 32(1):79-89.
PubMed

Characterization of the human porin isoform 1 (HVDAC1) gene by amplification on the whole human genome: A tool for porin deficiency analysis.
Messina A, Guarino F, Oliva M, van den Heuvel LP, Smeitink J, De Pinto V.
(2000) Biochem Biophys Res Commun. 270(3):787-92.
PubMed

Porin is present in caveolae and caveolae-related domain
G. Bathori, I. Parolini, F. Tombola, I. Szabō, A. Messina, M. Oliva, V. De Pinto, M. Lisanti, M. Sargiacomo and M. Zoratti
(1999) J. Biol. Chem., 274, 29607-12
PubMed

Mapping of the Human Voltage Dependent Anion Channel (VDAC) isoforms 1 and 2 reconsidered
Messina, A., Oliva, M., Rosato, C., Huizing, M., van der Heuvel, L.P., Forte, M., Rocchi, M. and De Pinto, V.
(1999) Biochem. Biophys. Res. Comm. 255, 707-10
PubMed

Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database
C. Caggese, G. Ragone, B. Perrini, R. Moschetti, V. De Pinto, R. Caizzi and P. Barsanti
(1999) Mol. Gen. Genetics 261, 64-70PubMed

Sequence of the Drosophila melanogaster mitochondrial porin gene: evidence of a conserved protein domain between fly and mouse
M. Oliva, A. Messina, G. Ragone, C. Caggese, R. Caizzi and V. De Pinto
(1998) FEBS Lett. 430, 327-332 PubMed

Disturbances in mitochondrial transport systems leading to encephalomyopathies

Trijbels F, Huizing M, Ruitenbeek W, Sengers R, Smeitink J, De Pinto V, Wendel U
(1998) Biofactors 7, 225-7 PubMed

Evaluation of biotinylated cells as a source of antigens for characterization of their molecular profile
F. Perosa, G. Luccarelli, M. Neri, V. De Pinto, S. Ferrone and F. Dammacco
(1998) Int. J. Clin. Lab. Res. 28, 246-251 PubMed

Double-stranded DNA can be translocated across a planar membrane containing purified mitochondrial porin
I. Szabo, G. Bāthori, F. Tombola, A. Coppola, I. Schmehl, M. Brini, A. Ghazi, V. De Pinto and Mario Zoratti
(1998) FASEB J. 12, 495-502 PubMed

DNA can be translocated across planar bilayer membranes containing mitochondrial porin
G. Bāthori, I. Szabo', F. Tombola, M. Brini, A. Coppola, M. Zoratti and V. De Pinto
(1997) Biophys. J. 72, A348

Deficiency of the Voltage-Dependent Anion Channel: clinical and biochemical aspects of a new mitochondriopathy
M. Huizing, W.Ruitenbeek, F.Thinnes, V. De Pinto, U. Wendel, J.M.F. Trijbels, L.M.E. Smit and L.P. van den Heuvel
(1996) Ped. Research 39, 1-6

Cloning and chromosomal localization of a cDNA encoding a mitochondrial porin from Drosophila melanogaster
A. Messina, M. Neri, F. Perosa, C. Caggese, M. Marino, R. Caizzi e V. De Pinto
(1996) FEBS Lett. 384, 9-13
PubMed

Deficiency of the Voltage-Dependent Anion Channel (VDAC): a novel cause of mitochondrial myopathies 
M.Huizing, W.Ruitenbeek, F.Thinnes and V. De Pinto
(1994) The Lancet 344, 762
PubMed

Location of the dicyclohexylcarbodiimide-reactive glutamate residue in bovine heart mitochondrial porin
V. De Pinto, J.A.Al Jamal, and F.Palmieri
(1993) J. Biol. Chem., 268, 12977-12982
PubMed

Purification and characterization of porin from corn (Zea mays L.) mitochondria
J.A.Aljamal, G.Genchi, V. De Pinto, L.Stefanizzi, A.DeSantis, R.Benz and F.Palmieri
(1993) Plant Physiol. 102, 615-621
PubMed

The mitochondrial permeability transition pore may comprise VDAC molecules. II. The electrophysiological properties of VDAC are compatible with those of the mitochondrial megachannel
I.Szabo, V. De Pinto and M. Zoratti
(1993) FEBS Lett. 330, 206-210
PubMed

Transmembrane arrangement of mitochondrial porin or Voltage-Dependent Anion Channel
V. De Pinto and F.Palmieri MINI-REVIEW
(1992) J. Bioenergetics and Biomembranes 24, 21-26
PubMed

Peptide-specific antibodies and proteases as probes of the transmembrane topography of the bovine heart mitochondrial porin
V. De Pinto, F.Thinnes, T.Link and F.Palmieri
(1991) Biochemistry 30, 10191-10200
PubMed

Characterization of SH-groups in porin of bovine heart mitochondria: porin cysteines are localized in the channel walls
V. De Pinto, J.A.Al Jamal, R.Benz and F.Palmieri
(1991) Eur. J. Biochem. 202, 903-911
PubMed

La Porina
V. De Pinto
(1990) Le Scienze (italian edition of Scientific American) 260, 34-42


Interaction of non-classical detergents with the mitochondrial porin

V. De Pinto, R.Benz and F.Palmieri
(1989) Eur. J. Biochem. 183, 179-187 PubMed

Purification of Glutamine Synthetase II isozyme of Drosophila melanogaster and structural and functional comparison of Glutamine Synthetase I and II
V. De Pinto, C.Caggese, G.Prezioso and F.Ritossa
(1987) Biochemical Genetics 25, 821-836
PubMed

A simple and rapid method for the purification of the mitochondrial porin from mammalian tissues
V. De Pinto, G.Prezioso and F.Palmieri
(1987) Biochim. Biophys. Acta 905, 499-502
PubMed

Porin pores of mitochondrial outer membranes from high and low eukaryotic cells: biochemical and biophysical characterization
V. De Pinto, O.Ludwig, J.Krause, R.Benz and F.Palmieri
(1987) Biochim. Biophys. Acta 894, 109-119
PubMed

The 35 kDa DCCD-binding protein from pig heart mitochondria is the mitochondrial porin
V. De Pinto, M.Tommasino, R.Benz and F.Palmieri
(1985) Biochim. Biophys. Acta 813, 230-242
PubMed

Purification and genetic control of NAD-dependent Glutamate Dehydrogenase from Drosophila melanogaster
C.Caggese, V. De Pinto and A.Ferrandino
(1982) Biochemical Genetics 20, 449-460
PubMed

Purification of the active mitochondrial phosphate carrier by affinity chromatography with an organomercurial agarose column
V. De Pinto, M.Tommasino, F.Palmieri and B.Kadenbach
(1982) FEBS Lett. 148, 103-106 PubMed



















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